Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion
نویسندگان
چکیده
منابع مشابه
TDP-43 suppresses tau expression via promoting its mRNA instability
In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we investigated the role of TDP-43 in tau expression in vitro and in vivo. We found that TDP-43 suppress...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2018
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12976